Thermx

About

Thermx  Ingredient Profile:

Focus: How the ingredients may assist in thermogenic & fat loss benefits

Vitamin B-6 (as Pyridoxine Hydrochloride) 25mg

Vitamin B-6 plays a central role in how the body metabolises fat, protein, and carbohydrates, helping convert the food you eat into usable energy rather than stored fat. It supports the enzymatic pathways involved in fat breakdown and amino acid metabolism, making it a foundational nutrient in any formula built around active energy metabolism and lean physique support.

Iodine (from Kelp) 150mcg

Iodine is essential for healthy thyroid function, and the thyroid gland is the body’s primary regulator of metabolic rate, heart rate, and calorie-burning capacity. Kelp has been prized for centuries as a rich natural source of iodine, and adequate iodine intake supports the thyroid hormone production needed to keep metabolism running efficiently.

Chromium (Amino Acid Chelate) 100mcg

Chromium supports healthy insulin sensitivity and glucose metabolism, helping the body use carbohydrates for energy rather than storing them as fat. A meta-analysis of ten randomised, placebo-controlled trials found chromium picolinate supplementation produced a statistically significant reduction in body weight compared to placebo, along with favourable changes in lean body mass and body fat percentage.

Acai (4:1 Extract) 400mg

Acai berry is rich in anthocyanins and polyphenol antioxidants, compounds associated with supporting healthy metabolic function and combating the oxidative stress that can accompany intense training and fat-burning phases. It’s a popular addition to fat-loss stacks for its nutrient density and its role in supporting overall metabolic and cardiovascular health alongside the formula’s more directly thermogenic actives.

Guarana 300mg* (33% Extract Providing 100mg Naturally Occurring Caffeine)

Guarana is a natural caffeine source that has shown real results in clinical research on fat loss. In an 8-week randomised, double-blind trial, a guarana-containing supplement produced significantly greater weight and fat loss than placebo over the study period. Caffeine itself is one of the most well-studied thermogenic compounds, increasing resting metabolic rate and enhancing fat oxidation by stimulating the sympathetic nervous system.

Theobromine 100mg*

Theobromine is a naturally occurring compound closely related to caffeine, found alongside it in guarana and cacao. It contributes to the stimulant, energising profile of the formula and has traditionally been included in thermogenic blends for its mild cardiovascular and metabolic-supporting effects alongside caffeine and catechins.

Green Tea Leaf 50mg* 98% Extract (14mg Naturally Occurring Caffeine, std. to 45% EGCG / 75% Polyphenol Catechins)

Green tea’s EGCG and catechin polyphenols are among the best-researched fat-loss compounds available. Human trials in metabolic chambers have repeatedly shown that green tea catechins combined with caffeine significantly increase 24-hour energy expenditure and fat oxidation, with one landmark study finding continuous ingestion of a high-catechin green tea extract meaningfully reduced body fat in a trial of over 200 men and women. The proposed mechanism involves inhibiting the enzyme that breaks down noradrenaline, prolonging its fat-burning, thermogenic signal in the body.

Garcinia Cambogia (50% Hydroxycitric Acid) 125mg*

Garcinia Cambogia’s hydroxycitric acid (HCA) works by inhibiting a key enzyme (ATP-citrate lyase) involved in converting excess carbohydrates into stored fat. A systematic review and meta-analysis of randomised clinical trials found HCA produced a small but statistically significant weight loss advantage over placebo, and it’s widely used in combination thermogenic formulas alongside caffeine and chromium for its complementary fat-metabolism mechanism.

Gymnema Sylvestre

Gymnema is best known for its ability to blunt sweet-taste perception via gymnemic acids, helping curb the sugar cravings that can derail a cutting phase. Clinical trials have shown participants using gymnemic acid supplements consumed significantly fewer sweet treats than placebo groups, supporting its role in this blend as a craving-control component that complements the formula’s fat-burning actives.

Banaba (1% Extract)

Banaba leaf’s corosolic acid has repeated human trial support for improving glucose uptake and lowering post-meal blood sugar levels, in some studies within 60 minutes of dosing. By supporting healthier blood sugar regulation, banaba may help the body favour fat as a fuel source rather than storing excess circulating glucose.

Calcium Pyruvate

Pyruvate has a following in fat-loss circles for its role in the body’s energy-producing glycolytic pathway. A placebo-controlled clinical trial found that 6g/day of pyruvate over six weeks produced a statistically significant reduction in body weight and body fat compared to placebo in overweight participants following a structured exercise programme, giving this ingredient genuine trial backing at higher doses.

Apple Cider Vinegar (Powder)

Apple cider vinegar has strong and growing clinical support for weight management. A 2025 systematic review and meta-analysis of ten randomised controlled trials found daily ACV intake significantly reduced body weight, BMI, and waist circumference, with a standalone 12-week clinical trial also reporting reduced appetite score and visceral adiposity index alongside body weight reduction.

Grapefruit (Powder)

Grapefruit’s flavonoid compounds, particularly naringin, have shown a genuine thermogenic synergy in clinical research: a randomised, placebo-controlled trial found that naringin combined with bitter-orange derived p-synephrine produced a significant increase in resting metabolic rate beyond either compound alone, and human intervention studies have linked regular grapefruit consumption to improved body composition and insulin sensitivity.

Coleus Forskohlii (Herb Powder)

Coleus Forskohlii’s active compound, forskolin, activates an enzyme (adenylate cyclase) that raises cyclic AMP levels in cells, a pathway that releases stored fatty acids for use as energy. A randomised controlled trial in overweight and obese men found forskolin supplementation produced significant reductions in body fat percentage and increases in lean body mass compared to placebo, and a broader evidence review concluded C. forskohlii extract showed a substantial effect on reducing body fat in overweight and obese individuals.

White Willow Bark (Herb Powder)

White willow bark contains natural salicin, chemically related to salicylic acid, and has traditionally been paired with caffeine-containing thermogenics to help potentiate and prolong their fat-burning, sympathetic nervous system effects — a role it has played in classic “thermogenic stack” formulations for decades.

Uva Ursi (Powder)

Uva ursi has a long traditional history as a natural diuretic, helping the body manage fluid balance and reduce the water retention that can obscure visible definition during a cutting or shredding phase. It’s commonly paired with juniper berry and buchu leaf in herbal formulas specifically for this water-balance support role.

Juniper Berry (Powder)

Juniper berry is a traditional diuretic herb, valued for supporting healthy fluid balance and helping the body flush excess water — a popular addition to “shredding” blends aimed at achieving a leaner, more defined look alongside genuine fat-loss actives.

Buchu Leaves (Herb Powder)

Buchu leaf rounds out the diuretic trio in this blend alongside uva ursi and juniper berry, with a traditional reputation for supporting the urinary system and healthy fluid elimination, helping reduce the bloated feeling that can accompany a calorie-restricted training phase.

Cayenne Pepper (Powder)

Cayenne’s capsaicin content is one of the most robustly studied natural thermogenic compounds. A systematic review and meta-analysis of 13 placebo-controlled clinical trials found capsaicinoids significantly increased resting metabolic rate, energy expenditure, and fat oxidation in healthy adults, and a 2024 randomised trial found a sustained-release capsaicin formulation produced a dose-dependent increase in energy expenditure, fat oxidation, and reduction in body weight over 28 days.

Naringin

Naringin is the grapefruit-derived flavonoid responsible for much of citrus’s thermogenic reputation. As above, clinical research found naringin paired with p-synephrine significantly boosted resting metabolic rate beyond synephrine alone, making it a genuine synergistic fat-metabolism compound rather than a filler ingredient.

Pantothenic Acid

Pantothenic acid (vitamin B5) is a essential cofactor in the synthesis of coenzyme A, the molecule central to breaking down fats, carbohydrates, and proteins for energy inside every cell. Its inclusion supports the fundamental cellular machinery that all the formula’s other fat-burning ingredients rely on to actually convert fat into usable energy.

L-Tyrosine

L-Tyrosine is the amino acid building block for noradrenaline and dopamine, the very neurotransmitters that drive the “fight or flight” thermogenic response amplified by this formula’s caffeine and catechin content. Supplementing tyrosine is thought to help support sustained catecholamine output during a calorie-restricted, high-stimulant fat-loss phase.

Chitosan

Chitosan is a fibre derived from crustacean shells that’s been used in fat-loss formulas for its proposed ability to bind to dietary fat in the gut and reduce its absorption, giving it a mechanistically distinct role in this blend compared to the metabolism-boosting and appetite ingredients around it.

ALC (Acetyl L-Carnitine)

Acetyl L-Carnitine plays a direct, essential role in fat metabolism by shuttling fatty acids into the mitochondria where they’re burned for energy. A 2020 systematic review and meta-analysis of 37 randomised controlled trials found L-carnitine supplementation significantly reduced body weight, BMI, and fat mass, with the largest effects seen around a 2,000mg daily dose — making this one of the more evidence-backed ingredients in the blend.

Fisetin

Fisetin is a plant flavonoid recognised for its strong antioxidant profile, helping protect cells from the oxidative stress that comes with intense training and a calorie-deficit fat-loss phase, rounding out the formula’s cellular health support alongside its more direct metabolic actives.

Magnesium Phosphate

Magnesium is a cofactor in hundreds of enzymatic reactions in the body, including those involved in energy production and muscle function, supporting the overall metabolic demands of an active, fat-loss-focused training programme.

DMAE (Dimethylaminoethanol)

DMAE is included in performance and fat-loss stacks primarily for its reputation supporting mental focus and drive during training, complementing the energising, stimulant profile of the formula’s caffeine and theobromine content during workouts.

Reference Sources

1. Nagao, T. et al. “A Green Tea Extract High in Catechins Reduces Body Fat and Cardiovascular Risks in Humans.” Obesity, 2007.
2. Dulloo, A.G. et al. “Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans.” American Journal of Clinical Nutrition, 1999.
3. Boozer, C.N. et al. “An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial.” International Journal of Obesity, 2001.
4. Onakpoya, I. et al. “The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials.” Journal of Obesity, 2011.
5. Godard, M.P. et al. “Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men.” Obesity Research, 2005.
6. Loftus, H.L. et al. “Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects.” Nutrients, 2015.
7. Askarpour, M. et al. “Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials.” Clinical Nutrition ESPEN, 2020.
8. Panchal, S. et al. “The effect of Capsaicinoids or Capsinoids in red pepper on thermogenesis in healthy adults: A systematic review and meta-analysis.” Cited in PubMed, 2020 (13-study meta-analysis).
9. Roopashree, N. et al. “A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance.” Frontiers in Nutrition, 2024.
10. Pittler, M.H. & Ernst, E. “Chromium picolinate for reducing body weight: Meta-analysis of randomized trials.” International Journal of Obesity, 2003.
11. Ratamess, N.A. et al. “Effects of calcium pyruvate supplementation during training on body composition, exercise capacity, and metabolic responses to exercise.” Nutrition, 2005.
12. Mazza, E. et al. “Effect of Apple Cider Vinegar Intake on Body Composition in Humans with Type 2 Diabetes and/or Overweight: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Nutrients, 2025.
13. Ratamess, N.A. et al. “Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes.” International Journal of Medical Sciences, 2011.
14. Miura, T. et al. “Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid.” Evidence-Based Complementary and Alternative Medicine, 2012.
15. Fabroni et al. “The Effect of a 14-Day Gymnema sylvestre Intervention to Reduce Sugar Cravings in Adults.” Nutrients, 2022.